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. Author manuscript; available in PMC: 2014 Jun 15.
Published in final edited form as: Cell Rep. 2013 Sep 12;4(6):1262–1275. doi: 10.1016/j.celrep.2013.08.010

Figure 6. Increased expression of the progenitor marker Ngn3 in Nkx6.1-deficient beta cells.

Figure 6

(A,B) qRT-PCR (A) and Western blot analysis (B) of islets from Nkx6.1Δ adultβ and control mice at 6 wks for multiple transcription factor genes (A) or Ngn3 (B) (n=3). (C–L) Immunofluorescence staining of pancreata from Nkx6.1 Δadultβ and control mice at 6 wks (C–F) and 14 wks (G–L). Dashed lines represent islet area. Insets are magnifications of selected areas. Arrowhead in (K) points to a cell co-expressing insulin (Ins) and somatostatin (Som). Scale bar = 20 μm. Gluc, glucagon; PP, pancreatic polypeptide; Wk, week. Data are shown as mean ± SEM. *p<0.05, **p<0.01, ***p<0.001.