Table 4. Cox's proportional hazards analysis.

Factor	Hazard ratio (95% confidence interval)	P
Symptoms (positive/negative)	1.469 (0.307–7.024)	0.630
Alkaline phosphatase (U/L) (> 94/≤ 94)	1.742 (0.671–4.524)	0.254
Albumin (g/dL) (≤ 3.5/> 3.5)	2.497 (1.001–6.297)	0.049
CEA (ng/dL) (> 5/≤ 5)	1.306 (0.542–3.148)	0.552
Tumor size (cm) (> 5/≤ 5)	1.065 (0.387–2.934)	0.903
Margin (positive/negative)	2.543 (1.13–4.352)	0.043
Lymph node status (positive/negative)	0.868 (0.371–2.034)	0.745
HSP90, PTEN (low, low or high, high/low, high)	5.820 (2.138–15.844)	0.001
(high, low/low, high)	5.471 (1.930–15.507)	0.001
Post-op radiotherapy (with/without)	1.494 (0.454–4.922)	0.509

HSP90: heat shock protein 90; PTEN: phosphatase and tensin homolog; NS: not significant