Table 2. Cox univariate and multivariate analysis of overall survival in HM and UAMS-TT2 patients' cohorts.
A) Cox univariate analysis of overall survival. The prognostic factors were tested as single variable. B) Cox multivariate analysis of overall survival. The DRscore were tested together with each of the prognostic factors. C) Cox multivariate analysis of overall survival using all prognostic factors together. Hazard ratios (HR) and P-values are shown. * A spike expression of MMSET gene was used a surrogate marker for t(4;14) as described[27]. NS, Not Significant at a 5% threshold; GPI, gene expression based proliferation index; ISS, International Staging System; UAMS-HRS, high-risk score from UAMS; IFM, Intergroupe Francophone du Myelome.
| A | Univariate Cox analysis - Overall survival | B | Multivariate Cox analysis - Overall survival | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HMS | UAMS - TT2 | HMS | UAMS - TT2 | |||||||
| HR | P | HR | P | HR | P | HR | P | |||
| DRScore | 9 | 4.0E-11 | 1.9 | 1.6E-03 | DRScore | 10 | 1.3E-10 | 1.1 | NS | |
| UAMS HRS | 2.4 | 1.4E-02 | 4.7 | 4.8E-13 | UAMS HRS | 0.75 | NS | 4.4 | 1.8E-09 | |
| IFM score | 2.5 | 1.9E-02 | 1.8 | 4.0E-03 | DRScore | 9 | 2.1E-10 | 1.6 | 1.8E-02 | |
| GPI | 2.6 | 1.6E-04 | 1.8 | 2.2E-04 | IFM score | 1 | NS | 1.5 | 4.8E-02 | |
| RS score | 4.2 | 3.3E-09 | 1.9 | 1.0E-05 | DRScore | 8.2 | 6.4E-08 | 1.4 | NS | |
| t(4;14)* | 3.3 | 4.7E-04 | 2.2 | 3.2E-04 | GPI | 1.2 | NS | 1.5 | 1.5E-02 | |
| del17p | 3.4 | 2.0E-02 | 2.5 | 3.7E-04 | DRScore | 4.9 | 2.4E-04 | 1.2 | NS | |
| ISS | 2 | 9.7E-04 | 1.6 | 5.5E-05 | RS score | 1.9 | 2.3E-02 | 1.8 | 1.5E-03 | |
| B2M | 1.1 | 4.2E-05 | 1.1 | 4.9E-08 | DRScore | 8.2 | 8.4E-10 | 1.7 | 1.1E-02 | |
| Alb | 0.47 | 1.4E-02 | 0.94 | 1.2E-04 | t(4;14)* | 2.2 | 3.0E-02 | 2 | 2.9E-03 | |
| DRScore | 11 | 1.8E-11 | 1.7 | 9.3E-03 | ||||||
| del17p | 2.8 | NS | 2.1 | 3.2E-03 | ||||||
| C | Multivariate Cox analysis - Overall survival | DRScore | 8.8 | 1.6E-10 | 1.7 | 1.1E-02 | ||||
| HMS | UAMS - TT2 | ISS | 1.8 | 3.3E-03 | 1.5 | 3.4E-04 | ||||
| HR | P | HR | P | DRScore | 9.1 | 5.8E-11 | 1.6 | 1.4E-02 | ||
| DRScore | 18 | 2.1E-07 | 0.64 | NS | B2M | 1.1 | 1.0E-04 | 1.1 | 2.1E-06 | |
| UAMS HRS | 0.55 | NS | 3.5 | 6.8E-06 | DRScore | 9.2 | 1.8E-11 | 1.7 | 8.8E-03 | |
| IFM score | 0.34 | NS | 0.95 | NS | Alb | 0.44 | 8.2E-03 | 0.95 | 6.6E-04 | |
| GPI | 0.86 | NS | 1.3 | NS | ||||||
| RS score | 1.1 | NS | 1.1 | NS | ||||||
| t(4;14)* | 2.7 | 3.8E-02 | 2.4 | 7.5E-04 | ||||||
| del17p | 3.1 | NS | 2.6 | 2.6E-04 | ||||||
| ISS | 2.9 | 2.0E-04 | 1.5 | 1.3E-03 | ||||||