Table 3. Cox univariate and multivariate analysis of event free survival (EFS) in HM and UAMS-TT2 patients' cohorts.
A) Cox univariate analysis of EFS. The prognostic factors were tested as single variable. B) Cox multivariate analysis of EFS. The DRscore were tested together with each of the prognostic factors. C) Cox multivariate analysis of EFS using all prognostic factors together. Hazard ratios (HR) and P-values are shown. * A spike expression of MMSET gene was used a surrogate marker for t(4;14) as described[27]. NS, Not Significant at a 5% threshold; GPI, gene expression based proliferation index; ISS, International Staging System; UAMS-HRS, high-risk score from UAMS; IFM, Intergroupe Francophone du Myelome.
| A | Univariate Cox analysis - Event free survival | B | Multivariate Cox analysis - Event free survival | |||||||
|---|---|---|---|---|---|---|---|---|---|---|
| HMS | UAMS - TT2 | HMS | UAMS - TT2 | |||||||
| HR | P | HR | P | HR | P | HR | P | |||
| DRScore | 3.1 | 1.4E-07 | 2.1 | 1.2E-06 | DRScore | 2.9 | 9.7E-06 | 1.6 | 6.6E-03 | |
| UAMS HRS | 1.9 | 5.3E-03 | 3.5 | 3.8E-11 | UAMS HRS | 1.2 | NS | 2.7 | 2.6E-06 | |
| IFM score | 1.9 | 1.6E-02 | 1.9 | 5.2E-05 | DRScore | 2.9 | 2.7E-06 | 1.9 | 1.3E-04 | |
| GPI | 1.8 | 3.3E-04 | 1.5 | 4.1E-04 | IFM score | 1.2 | NS | 1.6 | 5.8E-03 | |
| RS score | 2 | 2.7E-06 | 1.7 | 9.3E-06 | DRScore | 2.6 | 1.3E-04 | 1.9 | 6.5E-04 | |
| t(4;14)* | 3.1 | 2.9E-05 | 2.4 | 9.2E-07 | GPI | 1.3 | NS | 1.2 | NS | |
| del17p | 3.4 | 2.5E-03 | 2 | 1.3E-03 | DRScore | 2.1 | 6.9E-03 | 1.7 | 7.2E-03 | |
| ISS | 1.3 | 2.3E-02 | 1.5 | 7.2E-07 | RS score | 1.5 | 4.3E-02 | 1.4 | 3.5E-02 | |
| B2M | 1 | 6.7E-03 | 1.1 | 6.7E-10 | DRScore | 2.7 | 1.0E-05 | 2 | 1.4E-05 | |
| Alb | 0.68 | 5.0E-02 | 0.96 | 2.8E-03 | t(4;14)* | 2.3 | 3.6E-03 | 2.2 | 1.5E-05 | |
| DRScore | 3.3 | 7.6E-08 | 2 | 1.0E-05 | ||||||
| del17p | 2.7 | 1.4E-02 | 1.7 | 1.6E-02 | ||||||
| C | Multivariate Cox analysis - Event free survival | DRScore | 3.4 | 2.7E-08 | 1.9 | 2.9E-05 | ||||
| HMS | UAMS - TT2 | ISS | 1.3 | 4.8E-02 | 1.5 | 1.5E-05 | ||||
| HR | P | HR | P | DRScore | 3.3 | 4.9E-08 | 1.9 | 6.6E-05 | ||
| DRScore | 2.4 | 8.7E-03 | 1.1 | NS | B2M | 1 | 4.1E-02 | 1.1 | 1.7E-07 | |
| UAMS HRS | 1 | NS | 1.8 | 1.4E-02 | DRScore | 3.1 | 1.1E-07 | 2 | 7.9E-06 | |
| IFM score | 1.1 | NS | 1.3 | NS | Alb | 0.67 | 4.9E-02 | 0.97 | 1.9E-02 | |
| GPI | 1.1 | NS | 1.3 | NS | ||||||
| RS score | 1.1 | NS | 0.94 | NS | ||||||
| t(4;14)* | 2.3 | 9.2E-03 | 2.6 | 8.4E-06 | ||||||
| del17p | 2.7 | 2.6E-02 | 2.1 | 1.1E-03 | ||||||
| ISS | 1.4 | 3.8E-02 | 1.5 | 3.2E-05 | ||||||