Table 3. Multivariate COX regression models for overall survival.

Variable	Hazard ratio	95% CI	p value
COX model of Classification, IDH1/2, ATRX and Ki-67
Classification(A1 vs. A2 vs. A3)	0.464	0.193-1.115	0.086
IDH1/2 (Mut vs. Wt)	2.884	1.137-7.313	0.026
ATRX (Low vs. High)	2.665	1.386-5.123	0.003
Ki-67 (Low vs. High)	5.626	2.337-13.545	<0.0001
COX model of Classification and Grade
Classification(A1 vs. A2 vs. A3)	1.541	1.078-2.204	0.018
Grade (A vs. AA vs. GBM)	2.095	1.468-2.990	<0.0001

Abbreviations: A, astrocytoma; AA, anaplastic astrocytoma; Mut, mutation; Wt, wild type.