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. 2014 Mar 21;5(9):2562–2574. doi: 10.18632/oncotarget.1812

Figure 8. Proposed model for the effects of IGF-1R-mediated let-7b on the AKT/MAPK pathways and thereby proliferation.

Figure 8

Expression of let-7b downregulates the target genes expression, including IGF-1R and IRS-2. IGF-1R is essential factor required for the activation of direct IRS-2 phosphorylation and indirect ERE1/2 phosphorylation(p-ERK1/2) vis MAPK pathway. p-ERK1/2 is translocated into nuclears to activate the transcription of IRS-2 through regulation of transcription factors. As results of IRS-2 activation, Akt pathway involved in proliferation is promoted.