Table 1. Genomic aberrations in MYCN/Alk tumors defined by array-CGH. Abnormalities are indicated for each tumor together with the genotype, genetic background, sex and age of the mouse. 129B6F1: F1 background from 129×1/SvJ × C57Bl6/N intercrosses.
Tumor | Genotype | Genetic background | Sex | Age in days | Abnormalities in CGH |
---|---|---|---|---|---|
tumor 31 | MYCN / KI AlkF1178L | 129S2 | F | 36 | 0 |
tumor 28 | MYCN / KI AlkF1178L | 129S2 | M | 37 | 0 |
tumor 29 | MYCN / KI AlkF1178L | 129S2 | F | 44 | 0 |
tumor 30 | MYCN / KI AlkF1178L | 129S2 | M | 36 | 0 |
tumor 13 | MYCN / KI AlkR1279Q | 129S2 | M | 67 | 0 |
tumor 14 | MYCN / KI AlkR1279Q | 129S2 | M | 75 | 0 |
tumor 16 | MYCN / KI AlkR1279Q | 129S2 | M | 59 | 0 |
tumor 18 | MYCN / KI AlkR1279Q | 129S2 | M | 58 | 0 |
tumor 19 | MYCN / KI AlkR1279Q | 129S2 | M | 59 | 0 |
tumor 2 | MYCN / KI AlkF1178L | 129B6F1 | M | 133 | 2- 4- 3+ 6+ 12+ 13- 14- 16- |
tumor 1 | MYCN / KI AlkF1178L | 129B6F1 | M | 133 | 11+ |
tumor 4 | MYCN / KI AlkF1178L | 129B6F1 | F | 91 | 3+ 17+ |
tumor 11 | MYCN / KI AlkF1178L | 129B6F1 | F | 98 | 0 |
tumor 38 | MYCN / KI AlkF1178L | 129B6F1 | F | 134 | 3+5-15q-16- |
tumor 37 | MYCN / KI AlkF1178L | 129B6F1 | M | 64 | 0 |
tumor 8 | MYCN / KI AlkR1279Q | 129B6F1 | F | 181 | 4-5-6+10+12+13-14-17+19- |
tumor 5 | MYCN / KI AlkR1279Q | 129B6F1 | F | 116 | 4- 4qA3+15qE2- |
tumor 9 | MYCN / KI AlkR1279Q | 129B6F1 | M | 190 | 2q+11q+ 15qF3- |