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. 2014 Apr 18;5(9):2778–2791. doi: 10.18632/oncotarget.1916

Figure 3. Sensitivity of clonal A549 populations to high dose olaparib (5 μM) before.

Figure 3

(A) and after (B) IDO induction. Results were obtained from 3 independent clonal cell populations harboring scrambled control shRNA or anti-IDO shRNA, and each bar represents the mean of the 3 values (n=3 for determination of each value) ± SEM (*, P ≤ 0.05). Sensitivity of clonal HeLa populations to olaparib (5 M) before (C) and after (D) IDO induction. Results were obtained from 3 independent clonal cell populations harboring scrambled control shRNA or anti-IDO shRNA, and each bar represents the mean of the 3 values (n=3 for determination of each value) ± SEM (*, P ≤ 0.05). Induction of IDO in A549 (E) and HeLa (F) clonal cell populations decreases the effectiveness of olaparib. Results were obtained from 3 independent clonal cell populations with scrambled control shRNA or anti-IDO shRNA, and each bar represents the mean of the 3 values (n=3 for determination of each value) ± SEM (*p≤0.05).