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. 2014 Apr 18;5(9):2778–2791. doi: 10.18632/oncotarget.1916

Figure 6. A549 (A-B) and HeLa (C-D) sensitivity to combined gamma irradiation (4 Gy) and olaparib (5 microM) treatment before (A and C) and after (B and D) IDO induction.

Figure 6

Results were obtained from independent measurements of proliferation of 3 A549 or HeLa clonal populations (2 independent experiments for each population) with control scrambled shRNA and 3 with anti-IDO shRNA. Bars represent the means of those 3 independent measurements (n=3 for each measurement) ± SEM (*p≤0.05). IDO in A549 (E) or HeLa (F) clones decreases the effectiveness of combined gamma irradiation and olaparib treatment. Bars represent the means of 3 independent measurements (n=3 for each measurement) SEM. *Different from cells treated identically but without IFN gamma induction (p≤0.05, Student's t-test).