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. 2014 Apr 24;5(9):2807–2819. doi: 10.18632/oncotarget.1921

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Copyright: © 2014 Maitra et al.

This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.

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Figure 4a — Transmission electron micrograph of HCT116 and Hke3 cells upon 5MOI reovirus treatment for 48 hours. The KRAS mutant HCT116 cells show a much greater formation of viral crystalline Arrays (VCA's) indicative of the effective generation of infection competent virion particles. The images were photographed under 10K magnification. b. Graphical representation of the number of viral particles per array in HCT116 and Hke3 cells treated with 5MOI reovirus at for 48 hours. Three independent arrays were counted per cell line. A quantitative analysis of count of viral particle per array indicated 272.67 ± 3.71 (mean ± SEM) particles in HCT116 and 87±2.65 (mean ± SEM) particles in Hke3 cells. A significant p value of p≤0.005 was observed.