Table 1. Clinico-pathological features of 153 biliary carcinomas.
| Total (n=153) |
ICC (n=70) |
ECC (n=57) |
GBC (n=26) |
P-value* | ||
|---|---|---|---|---|---|---|
| Sex | 59F 94M | 28F 42M | 20F 37M | 11F 15M | 0.776 | |
| Age | 65.4±10.8 | 64.8±11.6 | 64.2±10.8 | 69.6±8.0 | 0.118 | |
| Dimension (cm) | 4.8±3.4 | 6.6±3.7 | 2.6±1.3 | 3.3±1.4 | 9.77 E-12 | |
| Multiple nodes | 31 (20.3%) |
28 (40.0%) |
3 (5.3%) |
- | 2.84 E-6 | |
| Grade | 1 | 20 (13.1%) |
7 (10.0%) |
8 (14.0%) |
5 (19.2%) |
0.630 |
| 2 | 94 (61.4%) |
45 (64.3%) |
36 (63.2%) |
13 (50.0%) |
||
| 3 | 38 (24.8%) |
18 (25.7%) |
12 (21.0%) |
8 (30.7%) |
||
| 4 | 1 (0.6%) |
0 (0.0%) |
1 (1.8%) |
0 (0.0%) |
||
| Presence of BiIIN | 49 (32.0%) |
11 (15.7%) |
24 (42.1%) |
14 (53.8%) |
0.0002 | |
| Vascular invasion | 107 (70.0%) |
51 (72.9%) |
38 (66.7%) |
18 (69.2%) |
0.773 | |
| Perineural invasion | 93 (60.8%) |
31 (44.3%) |
44 (77.2%) |
18 (69.2%) |
0.0005 | |
| Radicality of resection | R0 | 110 (71.9%) |
56 (80.0%) |
33 (57.9%) |
19 (73.1%) |
0.068 |
| R1 | 43 (28.1%) |
14 (20.0%) |
24 (42.1%) |
7 (26.9%) |
||
| HBV/HCV infection | 22 (14.4%) |
17 (24.3%) |
3 (5.3%) |
2 (7.7%) |
0.041 | |
| Cirrhosis | 13 (8.5%) |
10 (14.3%) |
3 (5.3%) |
0 (0.0%) |
0.005 | |
| Stage | I | 20 (13.1%) |
12 (17.1%) |
5 (8.8%) |
3 (11.5%) |
0.034 |
| II | 51 (33.3%) |
21 (30.0%) |
22 (38.6%) |
8 (30.7%) |
||
| III | 43 (28.1%) |
12 (17.1%) |
20 (35.1%) |
11 (42.3%) |
||
| IV | 39 (25.5%) |
25 (35.8%) |
10 (17.5%) |
4 (15.4%) |
Note: ICC, intrahepatic cholangiocarcinoma; ECC, extrahepatic cholangio-carcinoma; GBC, gallbladder carcinoma; BiIIN, biliary intraepithelial neoplasia
Fisher's exact test for categorical data, Kruskal-Wallis test for continuous variables.
# Chi-squared test with Monte Carlo simulation (2000 replicates).