Table 4. Multivariate survival analysis of 125 cholangiocarcinomas; median survival was 31 months and 79 subjects died of disease.
| Variable | Odds-ratio | 95% C.I. | P-value |
|---|---|---|---|
| Stage = I | 1 | - | - |
| Stage = II | 1.57 | 0.58-4.25 | 0.371 |
| Stage = III | 4.27 | 1.54-11.8 | 0.005 |
| Stage = IV | 4.85 | 1.68-14.0 | 0.003 |
| Vascular invasion = yes | 1.64 | 0.93-2.88 | 0.087 |
| Perineural invasion = yes | 0.63 | 0.36-1.08 | 0.093 |
| TP53 = mutated | 2.26 | 1.35-3.78 | 0.002 |
| KRAS = mutated | 1.51 | 0.91-2.51 | 0.110 |
| Excluded variables | |||
| Grade = 1 | 1 | - | - |
| Grade = 2 | 1.38 | 0.57-3.37 | 0.474 |
| Grade = 3 | 1.49 | 0.58-3.82 | 0.404 |
| Class = ICC | 1 | - | - |
| Class = ECC | 1.31 | 0.70-2.41 | 0.390 |
| Class = GBC | 0.67 | 0.30-1.49 | 0.323 |
| IDH1/2 = mutated | 1.26 | 0.50-3.17 | 0.631 |
Note: ICC, intrahepatic cholangiocarcinoma; ECC, extrahepatic cholangiocarcinoma; GBC, gallbladder carcinoma.