Table 2.
Allelic and genotypic frequency and association analysis of SNPs
| Gene | MDD | Control | ||
|---|---|---|---|---|
| SNPs | Number (percentage) | OR (95% CI) | p-value | Number (percentage) |
|
Cry1 rs2287161 |
||||
| CC | 80 (0.762) | 1.91 (1.16~3.14)a | 0.010 | 314 (0.647) |
| CG | 24 (0.229) | 150 (0.309) | ||
| GG | 1 (0.010) | 21 (0.043) | ||
| C | 184 (0.876) | 1.75 (1.12~2.71)b | 0.012 | 778 (0.802) |
| G | 26 (0.124) | 192 (0.198) | ||
|
Cry2 rs10838524 |
||||
| AA | 93 (0.886) | 1.65 (0.85~3.21)c | 0.138 | 407 (0.839) |
| AG | 12 (0.114) | 78 (0.161) | ||
| A | 198 (0.943) | 1.44 (0.77~2.70)d | 0.249 | 892 (0.920) |
| G | 12 (0.057) | 78 (0.080) | ||
|
Tef rs738499 |
||||
| TT | 82 (0.781) | 2.66 (1.60~4.41)e | <0.001 | 293 (0.604) |
| TG | 21 (0.200) | 160 (0.330) | ||
| GG | 2 (0.019) | 32 (0.066) | ||
| T | 185 (0.881) | 2.22 (1.42~3.46)f | <0.001 | 746 (0.769) |
| G | 25 (0.119) | 224 (0.231) |
Abbreviations: OR, Odds Ratio; 95% CI, 95% confidence intervals; MDD, Major Depressive Disorder;
a
CC/(CG+GG);
b
C/G;
c
AA/AG;
d
A/G;
e
TT/(TG+GG);
f
T/G.