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. 2014 May 23;3(6):503–509. doi: 10.1242/bio.20148441

Fig. 3. kar encodes endothelin-converting enzyme 2.

Fig. 3.

kar maps to a region at the beginning of chromosome 15 (A). One marker, G40280, is 100% linked to the mutation and lies in the gene coding for endothelin-converting enzyme 2 (A,C). Chromatograms of ece2 sequences from wild-type and kar mutant fish (B) showing the mutation (the premature Stop codon is underlined). Ece2 is a type II transmembrane protein of 765 aa (D), the C-terminal peptidase domain is lost in the mutants, TM: transmembrane domain. Phylogenetic analysis of the amino acid sequences of Eces from different vertebrate species shows three branches with Ece1, Ecel1 and Ece2 (E).