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. 2014 May 29;2014:124063. doi: 10.1155/2014/124063

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Copyright © 2014 Georg D. Duerr et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Attenuated remodeling in ischemic OPN⁻/⁻-hearts. (a) Representative section of left ventricle after 7 days I/R in a WT-heart shows numerous α-smac positive myofibroblasts (black arrows) in the ischemic myocardium. (b) At the same time point, α-smac positive signals (black arrow) were almost absent in small, nontransmural infarctions (white arrows) of OPN⁻/⁻-hearts. mRNA-induction of (c) tenascin-C (TNC), (d) MMP-2, (e) MMP-9, (f) MMP-12, (g) MMP-13, (h) TIMP-1, and (i) TIMP-2 in WT- and OPN⁻/⁻-hearts during repetitive I/R. n = 8–11/group. Scale bars represent 50 μm. RT-qPCR using Taqman and mRNA-expression is related to controls and GAPDH using comparative ΔΔCt-method. Bracket indicates P ≤ 0.05 between genotypes; ∗ indicates P ≤ 0.05 versus respective shams.