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. 2014 Jun 15;127(12):2659–2671. doi: 10.1242/jcs.139394

Fig. 7.

Fig. 7.

Calcineurin activation induces mitochondrial fission in cultured cardiomyocytes. (A) Representative confocal microscopy images of cells stained with Mitotracker Green after transduction with the adenovirus containing LacZ, CAIN or calcineurin (CN) and after norepinephrine (NE) stimulus (48 h). Scale bar: 5 µm. (B) Quantitative analysis of confocal microscopy images of cell treated as in A to evaluate mitochondrial morphology (mean±s.e.m.; n = 4). (C) Oxygen consumption assays of cardiomyocytes transduced with the indicated adenovirus and stimulated with norepinephrine for 48 h (mean±s.e.m.; n = 4). *P<0.05 versus non stimulated control; #P<0.05 versus norepinephrine-stimulated control.