Table 3.
IC50 values of wine constituents and reference inhibitors for COX-1, COX-2, and 5-LOX.
| Compound | IC50 ± SD (μM) | Ratio | IC50 ± SD (μM) | |
|---|---|---|---|---|
| COX-1 | COX-2 | COX-1/COX-2 | 5-LOX | |
| Resveratrol | 2.27 ± 1.17 | 3.40 ± 0.50 | 0.67 | — |
| Piceatannol | —* | — | 0.76 ± 0.35 | |
| Luteolin | — | — | 2.25 ± 1.75 | |
| Quercetin | — | — | 3.29 ± 2.25 | |
| Myricetin | — | — | 4.02 ± 2.37 | |
| Kaempferol | 43.82 ± 18.81 | — | — | |
| Ibuprofen | 13.14 ± 3.84 | 8.77 ± 2.55 | 1.49 | nt# |
| Indomethacin | 1.61 ± 0.72 | 10.12 ± 5.66 | 0.15 | nt |
| Zileuton | nt | nt | 4.71 ± 2.83 | |
Data is presented as the mean value ± SD. *IC50 > 50 μM concentration; #not tested.