Table 3.

Reasons for discontinuation of previous biologic therapy.

First biologic drug used
Primary failure	5
Secondary failure	2
Toxicity	3
Second biologic drug used
Primary failure	3
Secondary failure	4
Toxicity	0
Third biologic drug used
Primary failure	2
Secondary failure	1
Toxicity	0
Fourth biologic drug used
Primary failure	1
Secondary failure	0
Toxicity	0