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. 2014 May 26;2014:960258. doi: 10.1155/2014/960258

Table 1.

Description of the anti-inflammatory aspects of the studies included in systematic review.

References Scientific name Parts used Animal Dose Route Methods used Action mechanism
Trovato et al., 2001 [11] H. empetrifolium APME Wistar rats 100 mg/kg i.p. CIPE Inhibition of PG
Ozturk et al., 2002 [12] H. triquetrifolium DAPE Wistar rats 25–60 mg/kg i.p. CIPE Without mechanism
Rabanal et al., 2005 [13] H. canariense; H. glandulosum BME Swiss mice 0.25–1 mg/ear t.a. TPAIEE Inhibition of AA metabolism
Abdel-Salam 2005 [14] H. perforatum Commercial extract Sprague-Dawley rats 50–300 mg/kg s.c. CIPE Inhibition of the liberation of HIS, 5-HT, KN
Sánchez-Mateo et al., 2006 [15] H. reflexum BME Swiss mice 0.25–1 mg/ear t.a. TPAIEE Inhibition of PLA2, COX, and LOX
Nguemfo et al., 2007 [16] A. monticola SBMCME Wistar rats 75–300 mg/kg p.o. CIPE; HSIPE; AAIPE; DIPE Inhibition of AA metabolism
Šavikin et al., 2007 [17] H. perforatum; H. barbatum; H. hirsutum; H. richeri; H. androsaemum. DAPE Wistar rats 25–200 mg/kg p.o. CIPE Inhibition of NF-κB.
Frutuoso et al., 2007 [18] R. longifolia LAE Swiss mice; Wistar rats 10–100 mg/kg p.o. PILPS Inhibition of neutrophil
Ymele et al., 2013 [19] A. gabonensis SBAE Wistar rats 100–400 mg/kg p.o. CIPE; HSIPE Reduced liberation and action of His and 5-HT;
inhibition AA metabolism
Šavikin et al., 2007 [17] H. perforatum; H. barbatum; H. hirsutum; H. richeri; H. androsaemum. DAPE Wistar rats 25–200 mg/kg p.o. CIPE Inhibition of NF-κB.
Panthong et al., 2007 [20] G. hanburyi BEAE Sprague-Dawley rats 10–40 mg/kg p.o. EPPIEE; CIPE; AAIPE; GGICP Inhibition of the liberation of His, PG, KN
Castardo et al., 2008 [21] G. gardneriana LHE Swiss mice 30–300 mg/kg i.p. CIPE; HSIPE; TPAIPE; BKIPE; AAIPE MPOAA; SPIPE Inhibition of the activity of neuropeptides and PKC
Galati et al., 2008 [22] H. rumeliacum APME Wistar rats 50; 70 mg/kg i.p. CIPE Without mechanism
Martins et al., 2008 [23] G. brasiliensis FPO Wistar rats 100 mg/kg p.o. CIPE Without mechanism
dos Reis et al., 2009 [24] G. cambogia FPE Wistar rats 0.5; 1.0 g/kg p.o. CITNBS; MPOAA; EMPGE2 Inhibition COX-2 expression and production of PGE2
Zdunić et al., 2009 [25] H. perforatum FTOE Wistar rats 1.25 mL/Kg p.o. CIPE Without mechanism
Paterniti et al., 2010 [26] H. Perforatum ME Sprague-Dawley rats 2 mg/kg   PIL; MPOAA; MVP; CE Reduces the NF-κB translocation; inhibition the IκB-α degradation; attenuation of the expression of iNOS
Su¨ntar et al., 2010 [27] H. perforatum APOOE; APEE Sprague-Dawley rats; Swiss mice 50–400 mg/kg p.o. AcAICP Without mechanism
Otuki et al., 2011 [28] G. gardneriana LHE; BHE; SHE Swiss Webster mice 0.01–1 mg/ear t.a. COIEE; MPOAA Inflammatory signal transduction pathway not specified
Ozturk et al., 2011 [12] G. brasiliensis LEE Wistar rats 30–300 mg/kg p.o. CIPE; PILPS; GGICP Inhibition of the liberation of His, 5-HT, and BK
Santos et al., 2011 [29] C. nemorosa LHxE Swiss mice 50–200 mg/kg i.p. CIP; MTP; MTNF-α; GGICP Inhibition of the neutrophil migration

Abbreviations of parts used: APME: aerial parts methanol extract; APEE: aerial parts ethanolic extract; APOOE: aerial parts olive oil extract; BEAE: bark ethyl acetate extract; BHE: bark hydroalcoholic extract; BME: blossom methanol extract; DAPE: dried aerial parts extract; FPE: fruit peel extract; FPO: fruit pee oil; FTOE: flowering tops oil extracts; LAE: leaves aqueous extract; LHE: leaves hydroalcoholic extract; LEE: leaves ethanolic extract; LHxE: leaves hexanic extract; ME: methanolic extract; SBAE: stem bark aqueous extract; SBMCME: stem barks methylene chloride/methanol extract; SHE: seeds hydroalcoholic extract.

Abbreviations of administration routes: i.p.: intraperitoneal; p.o.: oral administration; t.a.: topical administration.

Abbreviations of methods used: AAIPE: arachidonic acid-induced paw edema; AcAICP: acetic acid-induced increase in capillary permeability; BKIPE: bradykinin induced paw edema; CE: cytokines expression; CIP: carrageenan-induced pleurisy; CIPE: carrageenan-induced paw edema; CITNBS: colitis induced by 2,4,6-trinitrobenzenesulfonic acid; DIPE; dextran-induced paw edema; COIEE: croton oil-induced ear edema; EMPGE2: evaluation of mucosal PGE2; EPPIEE: ethyl phenylpropiolate induced ear edema; GGICP: granulomatous growth induced by cotton pellet; HSIPE: histamine and serotonin induced paw edema; MPOAA: myeloperoxidase activity assay; MTNF-α: measurement of tumor necrosis factor alpha; MTP: measurement of total protein; PEILPS: peritonitis induced by lipopolysaccharide; PIL: peritonitis induced by ligature; PILPS: pleurisy induced by LPS; SPIPE: substance P induced paw edema; TPAIPE: 12-O-tetradecanoylphorbol 13-acetate induced paw edema.

Abbreviations of action mechanism: AA: arachidonic acid; BK: bradykinin; COX: cyclooxygenase; His: histamine; iNOS: inducible nitric oxide synthase; KN: kinins; LOX: lipoxygenase; MVP: measurement of vascular permeability; NF-κB: nuclear factor kappa B; PKC: protein kinase C; PLA2: phospholipase A2; PG: prostaglandin, 5-HT: 5-hydroxytryptamine.