Figure 1.

Schematic representation of molecular pathogenesis of osteoblastic metastases in prostatecancer. Once reached the bone, tumor cells produce factors that stimulate osteoblasts (OBLs) differentiation and activity. Tumor cells also produce factors that act on stromal cells and osteoblasts that in turn stimulate osteoclasts (OCL) differentiation, thus perturbing bone remodeling on both sides. Finally, osteoclasts resorb bone allowing the release of growth factors that stimulate tumor cells survival and growth, thus fuelling the vicious circle.