Table 2.
Index | GroupC | Brain | Liver | Kidney | Serum |
---|---|---|---|---|---|
MDA (nmol/mg prot or nmol/mL) | Model | 7.09 ± 1.27 | 4.31 ± 1.10 | 5.07 ± 0.71 | 7.07 ± 0.58 |
Control | 5.47 ± 0.62a | 2.23 ± 0.97a | 3.89 ± 0.51a | 5.21 ± 0.58a | |
VC | 4.87 ± 0.94b | 2.27 ± 0.36b | 3.80 ± 0.68a | 4.92 ± 0.22a | |
Low dose | 5.53 ± 0.39a | 3.21 ± 1.15 | 4.76 ± 0.77 | 5.11 ± 0.70a | |
Medium dose | 4.77 ± 0.51b# | 2.57 ± 0.48a | 3.61 ± 0.80b | 4.73 ± 0.20a | |
High dose | 4.16 ± 0.50b## | 2.03 ± 0.63b | 2.87 ± 0.53bA# | 5.44 ± 0.63a | |
| |||||
SOD (U/mg prot or U/mL) | Model | 139.29 ± 17.74 | 281.25 ± 31.04 | 153.42 ± 5.21 | 96.64 ± 4.39 |
Control | 211.64 ± 38.02b | 368.10 ± 35.78b | 195.91 ± 16.30b | 121.70 ± 9.45a | |
VC | 181.12 ± 29.52b | 384.02 ± 27.66b | 145.91 ± 16.87## | 131.65 ± 13.05a | |
Low dose | 158.62 ± 21.84a# | 349.21 ± 34.90aA | 171.10 ± 14.59aA# | 96.41 ± 10.65A | |
Medium dose | 167.80 ± 33.06a# | 353.29 ± 22.14bA | 184.68 ± 13.35bB | 102.26 ± 5.46A# | |
High dose | 175.24 ± 22.22b# | 320.61 ± 35.27aB# | 189.27 ± 14.75bB | 115.62 ± 8.24a | |
| |||||
GSH (mgGSH/g prot or mgGSH/L) | Model | 2.96 ± 0.70 | 1.10 ± 0.20 | 1.52 ± 0.25 | 6.81 ± 0.58 |
Control | 5.59 ± 0.86b | 1.72 ± 0.10b | 2.53 ± 0.16b | 12.56 ± 0.40b | |
VC | 3.93 ± 0.45a## | 1.59 ± 0.19a | 2.29 ± 0.26b | 7.68 ± 0.38## | |
Low dose | 4.52 ± 0.86a# | 1.30 ± 0.33# | 1.63 ± 0.35B## | 7.62 ± 0.34## | |
Medium dose | 5.83 ± 0.66bB | 1.56 ± 0.35b | 1.99 ± 0.29b# | 7.98 ± 0.21a## | |
High dose | 7.09 ± 0.98bB# | 2.32 ± 0.33bB## | 2.52 ± 0.33b | 9.17 ± 0.42bA## | |
| |||||
GSH-Px (U/mg prot or U/mL) | Model | × | 415.35 ± 47.62 | 114.84 ± 8.83 | 459.67 ± 27.24 |
Control | 657.42 ± 53.53b | 174.17 ± 11.01b | 680.33 ± 21.51b | ||
VC | 511.67 ± 23.93b## | 159.10 ± 16.63b | 626.41 ± 16.88b# | ||
Low dose | 430.81 ± 42.50B## | 151.54 ± 21.95b# | 508.21 ± 20.52aB## | ||
Medium dose | 602.80 ± 67.82bB# | 169.50 ± 16.33b | 650.73 ± 14.10bA | ||
High dose | 493.69 ± 34.11b## | 194.91 ± 20.63bB# | 576.38 ± 14.50bA## | ||
| |||||
CAT (U/g prot or U/mL) | Model | × | 295.67 ± 36.16 | 120.01 ± 13.85 | 5.42 ± 0.29 |
Control | 340.24 ± 34.51a | 166.53 ± 34.24b | 9.71 ± 0.70b | ||
VC | 394.63 ± 62.56b | 149.67 ± 29.17a | 12.91 ± 1.19b | ||
Low dose | 317.88 ± 22.79A | 148.28 ± 24.34a | 8.61 ± 0.47bB | ||
Medium dose | 403.77 ± 41.93b# | 233.29 ± 42.72bB# | 9.67 ± 0.20bA | ||
High dose | 522.61 ± 31.60bB## | 158.70 ± 24.30a | 11.42 ± 0.27b# | ||
| |||||
T-AOC (U/mg prot or U/mL) | Model | 0.83 ± 0.21 | 1.23 ± 0.10 | 0.59 ± 0.06 | 4.56 ± 0.39 |
Control | 1.41 ± 0.28b | 1.66 ± 0.17b | 1.00 ± 0.15b | 6.52 ± 0.28b | |
VC | 2.48 ± 0.23b## | 1.36 ± 0.22# | 0.46 ± 0.08## | 6.78 ± 0.04b | |
Low dose | 1.38 ± 0.22bB | 1.34 ± 0.10# | 1.18 ± 0.08bB# | 5.38 ± 0.23aA# | |
Medium dose | 1.53 ± 0.24bB | 1.58 ± 0.16b | 1.25 ± 0.11bB# | 5.85 ± 0.26bA# | |
High dose | 1.92 ± 0.15bB## | 1.88 ± 0.16bB# | 1.48 ± 0.13bB## | 6.31 ± 0.30b |
Values are the mean ± SD.
× means undetected.
a P < 0.05; b P < 0.01 compared with model group (all groups). A P < 0.05; B P < 0.01 compared with VC group (EAE groups). # P < 0.05; ## P < 0.01 compared with control group (VC and EAE groups). CVC group (100 mg/kg); low dose EAE group (100 mg/kg); medium dose EAE group (200 mg/kg); high dose EAE group (400 mg/kg).