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. Author manuscript; available in PMC: 2015 Jun 1.
Published in final edited form as: Mol Cancer Res. 2014 Mar 20;12(6):823–829. doi: 10.1158/1541-7786.MCR-13-0624

Figure 3. DNA-MS reveals APCR876* somatic mutation in a proximal dysplastic ACF.

Figure 3

A, DNA-MS reveals a c.2626C>T substitution resulting in an APCR876* mutation in a proximal dysplastic ACF. UEP = unextended primer. B, IHC demonstrates an accumulation of nuclear β-catenin (black arrowheads) in dysplastic crypts positive for the APCR876* mutation compared to adjacent normal crypts. (400× magnification; bar = 30 µm) C, Sanger sequencing confirms that the APCR876* mutation is somatically acquired. Blood and synchronous tubular adenomas are wild-type at codon 876 of APC.