Table 4.

Multivariable analysis of WMHv in subjects with acute ischemic stroke at baseline and 48 hours post-stroke.

Model 1
	B	95%CI for B		β	p
		Low	High
Gender	0.238	-0.025	0.501	0.090	0.08
Prior stroke	0.368	0.042	0.694	0.110	0.03
Hypertension	0.768	0.473	1.064	0.266	<0.001
Hyperlipidemia	-0.030	-0.304	0.244	-0.218	0.83
IV t-PA	-0.267	-0.539	0.004	-0.100	0.05
NIHSS at baseline	0.028	0.008	0.049	0.143	0.007
MMP-2 at baseline	0.0002	-0.0001	0.001	0.055	0.27
Model 2
Gender	0.362	0.052	0.671	0.138	0.02
Prior stroke	0.219	-0.184	0.621	0.064	0.29
Hypertension	0.640	0.294	0.985	0.231	<0.001
Hyperlipidemia	0.193	-0.127	0.514	0.075	0.24
IV t-PA	-0.160	-0.470	0.151	-0.061	0.31
NIHSS at 48 h	0.003	0.011	0.059	0.173	0.005
MMP-2 at 48 h	0.002	0.0001	0.003	0.121	0.047

Model 1 included all baseline variables associated with lnWMHv at p<0.2 in age-adjusted analyses

Model 2 includes all 48h variables associated with lnWMHv at p<0.2 in age-adjusted analyses

Abbreviations: IV tPA: intravenous tissue plasminogen activator; NIHSS: National Institutes of Health Stroke Scale; MMP: matrix metalloproteinase; lnWMHv: natural log of white matter hyperintensity volume