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. Author manuscript; available in PMC: 2015 Jun 15.
Published in final edited form as: Cancer Res. 2014 Apr 17;74(12):3282–3293. doi: 10.1158/0008-5472.CAN-13-2066

Figure 6. In Vivo Study of Notch3 siRNA in Mouse Models of Ovarian Cancer (OvCa).

Figure 6

(A–C) Effect of treatment with Notch3 siRNA and/or paclitaxel on tumor weight in Notch3 intracellular domain (NICD3)-positive models (OVCAR5 and A2780) and NICD3-negative model (SKOV3). The error bars represent standard error of the mean (SEM). *p < 0.05; **p < 0.01; ***p < 0.001. (D–G) Effect of treatment with Notch3 siRNA and/or paclitaxel on biological endpoints: cell proliferation (Ki67 expression), apoptosis (cleaved caspase-3 expression), Notch3 expression and microvessel density (CD31). Original magnification, 200×. The error bars represent standard error of the mean (SEM). *p < 0.05; **p < 0.01; ***p < 0.001.