Table 2. Pulmonary Function Test Distributions.
| Baseline (n=55) |
Week 6 Post-SBRT (n=41) | Month 3 Post-SBRT (n=27) | 2 Year Post-SBRT (n=24) | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| Pulmonary Function Test |
n | Raw | n | Raw | n† | Change since Baseline* |
n | Raw | n† | Change since Baseline* |
n | Raw | n† | Change since Baseline* |
| FVC (L) | 51 | 2.3 ± 0.7 | 40 | 2.4 ± 0.8 | 37 | 0.0 ± 0.5 | 26 | 2.3 ± 1.0 | 23 | -0.02 ± 0.4 | 23 | 2.5 ± 0.9 | 20 | 0.0 ± 0.5 |
| FVC (% Predicted) | 51 | 80.0 ± 23.0 | 40 | 81.4 ± 26.0 | 37 | -0.32 ± 18.6 | 26 | 78.7 ± 29.8 | 23 | 0.8 ± 10.5 | 23 | 81.4 ± 26.6 | 20 | 0.9 ± 16.6 |
| FEV1 (L) | 51 | 1.3 ± 0.6 | 40 | 1.2 ± 0.6 | 37 | -0.08 ± 0.3 | 26 | 1.1 ± 0.7 | 23 | -0.13 ± 0.3 | 23 | 1.1 ± 0.6 | 20 | -0.12 ± 0.3 |
| FEV1 (% Predicted) | 51 | 60.8 ± 33.2 | 40 | 57.1 ± 27.0 | 37 | -6.09 ± 25.2 | 26 | 53.3 ± 29.6 | 23 | -4.8 ± 11.0 | 23 | 51.0 ± 25.3 | 20 | -5.79 ± 13.5 |
| FEV1/FVC | 51 | 0.5 ± 0.2 | 40 | 0.5 ± 0.2 | 37 | -0.02 ± 0.1 | 26 | 0.5 ± 0.2 | 23 | -0.05 ± 0.1 | 23 | 0.5 ± 0.1 | 20 | -0.05 ± 0.1 |
| FEV1/FVC (% Predicted) | 51 | 70.0 ± 30.0 | 40 | 70.0 ± 20.0 | 37 | -5.0 ± 20.0 | 26 | 70.0 ± 20.0 | 23 | -7.0 ± 20.0 | 23 | 60 ± 20.0 | 20 | -7.0 ± 10.0 |
| RV (L) | 39 | 3.2 ± 1.0 | 34 | 3.3 ± 1.4 | 25 | 0.1 ± 1.2 | 18 | 3.1 ± 0.8 | 12 | -0.31 ± 0.4 | 12 | 3.5 ± 1.3 | 8 | -0.34 ± 1.1 |
| RV (% Predicted) | 39 | 154.6 ± 56.9 | 34 | 157.2 ± 59.4 | 25 | 5.0 ± 50.7 | 18 | 154.1 ± 45.7 | 12 | -17.8 ± 20.8 | 12 | 148.1 ± 49.8 | 8 | -20.8 ± 46.6 |
| TLC (L) | 39 | 5.7 ± 1.4 | 34 | 5.9 ± 1.6 | 25 | 0.2 ± 0.8 | 18 | 5.7 ± 0.9 | 12 | -0.23 ± 0.4 | 12 | 6.5 ± 1.6 | 8 | -0.38 ± 0.8 |
| TLC (% Predicted) | 39 | 113.1 ± 19.4 | 34 | 112.7 ± 20.8 | 25 | 2.6 ± 13.0 | 18 | 115.4 ± 16.7 | 12 | -1.24 ± 22.7 | 12 | 113.2 ± 18.5 | 8 | -9.17 ± 18.6 |
| DLCO (ml/min/mmHg) | 42 | 10.6 ± 3.6 | 38 | 9.5 ± 4.0 | 29 | -0.23 ± 1.7 | 25 | 9.5 ± 4.8 | 17 | -0.46 ± 2.3 | 17 | 10.7 ± 4.8 | 13 | -0.74 ± 2.4 |
| DLCO (% Predicted) | 42 | 60.7 ± 30.4 | 38 | 48.3 ± 23.0 | 29 | -3.4 ± 6.7 | 25 | 44.6 ± 18.1 | 17 | -5.39 ± 7.6 | 17 | 46.6 ± 18.1 | 13 | -6.29 ± 10.1 |
| PaCO2 (mmHg) | 37 | 40.5 ± 6.4 | 33 | 39.2 ± 7.4 | 25 | 0.0 ± 3.1 | 15 | 41.9 ± 10.8 | 14 | 0.3 ± 4.6 | 9 | 38.0 ± 5.5 | 7 | -0.9 ± 6.4 |
| PaO2 (mmHg) | 37 | 72.6 ± 13.9 | 33 | 72.0 ± 14.1 | 25 | 1.2 ± 15.2 | 15 | 68.4 ± 12.4 | 14 | -1.3 ± 16.0 | 9 | 74.0 ± 16.8 | 7 | 1.7 ± 5.4 |
| SaO2 (%) | 33 | 93.3 ± 4.4 | 31 | 93.2 ± 4.0 | 24 | 0.9 ± 4.7 | 15 | 92.5 ± 4.0 | 14 | -0.1 ± 4.9 | 10 | 94.0 ± 2.8 | 8 | 0.4 ± 3.9 |
L = Liter; n = number of patients; values are expressed as mean ± standard deviation;
*
Actual raw changes were calculated by subtracting the baseline value from the follow-up value;
†
Has both baseline and follow-up PFT. With the exception of DLCO (% predicted), all PFT changes were not statistically significant (p > 0.05). The change in DLCO (% predicted) was significant at 6 weeks (p = 0.008) and at 3 months (p = 0.007).