Table 2.
Group | Dose (mg/kg) | Mean blood glucose concentration ± SEM (mg/dL) | |||
---|---|---|---|---|---|
1st day | 3rd day | 5th day | 8th day | ||
Control | — | 107.90 ± 2.50 | 109.80 ± 3.60 | 108.86 ± 3.20 | 117.50 ± 4.70 |
Diabetic controla | — | 202.79 ± 5.60*** | 211.93 ± 4.50*** | 214.91 ± 9.70*** | 210.55 ± 7.30*** |
GBb | 5 | 186.70 ± 3.70 | 179.53 ± 2.90 | 161.54 ± 2.40** | 171.97 ± 3.10 |
Pg b | 25 | 138.67 ± 2.60 | 87.54 ± 1.70 | 158.63 ± 2.30 | 135.50 ± 2.10** |
Pg b | 50 | 143.34 ± 1.90 | 119.67 ± 1.70 | 119.33 ± 1.90 | 119.10 ± 1.10** |
Pg b | 100 | 132.12 ± 1.30 | 112.98 ± 2.50 | 124.36 ± 2.60 | 111.50 ± 2.50* |
Placebo F1 | 200 | 193.10 ± 3.10 | 212.66 ± 2.90 | 229.54 ± 2.80 | 226.33 ± 2.10 |
F1b | 50 | 144.11 ± 1.20 | 129.40 ± 1.60 | 130.66 ± 2.40 | 125.88 ± 3.10* |
F1b | 100 | 120.33 ± 1.70 | 115.60 ± 2.40 | 128.65 ± 2.90 | 124.33 ± 3.20* |
F1b | 200 | 125.21 ± 2.90 | 115.50 ± 3.10 | 108.40 ± 2.40 | 104.32 ± 1.90* |
Placebo F2 | 200 | 229.33 ± 2.50 | 226.89 ± 2.90 | 204.98 ± 3.10 | 265.44 ± 2.90 |
F2b | 50 | 175.50 ± 2.50 | 119.90 ± 2.10 | 119.10 ± 1.30 | 118.50 ± 1.90* |
F2b | 100 | 118.65 ± 1.30 | 128.10 ± 1.30 | 122.49 ± 2.40 | 117.65 ± 2.10* |
F2b | 200 | 191.33 ± 3.90 | 94.54 ± 1.40 | 108.55 ± 3.40 | 107.43 ± 2.50* |
GAb | 3 | 198.10 ± 1.90 | 208.00 ± 2.20 | 111.36 ± 3.30 | 101.88 ± 2.22* |
GAb | 6 | 179.65 ± 3.10 | 134.66 ± 2.60 | 130.54 ± 2.90 | 98.23 ± 2.87* |
GAb | 12 | 168.33 ± 2.90 | 140.50 ± 3.50 | 137.25 ± 2.70 | 118.55 ± 3.50* |
SEM: standard error of the mean.
*P < 0.05 significant from the control animals.
**P < 0.01 significant from the control animals.
***P < 0.001 significant from the control animals.
aCompared to vehicle control.
bCompared to diabetic control.