Table 2.
Effects of Ashwagandha water extract on lead induced oxidative damage to CAT, SOD, GSH, and LPx in rat brain regions, liver, and kidney.
| Groups | Kidney | Liver | Hippocampus | Hypothalamus | Cortex |
|---|---|---|---|---|---|
| Catalase (CAT)—units/minute/g | |||||
| C | 10.05 ± 1.37 | 3.72 ± 1.20 | 18.80 ± 1.95 | 11.47 ± 0.47 | 10.24 ± 1.52 |
| LN | 3.80 ± 1.68* | 4.95 ± 1.68* | 10.57 ± 1.83* | 4.58 ± 0.84* | 5.35 ± 1.20* |
| LN + AS | 12.37 ± 4.26# | 7.00 ± 1.71∗# | 9.56 ± 1.07* | 9.31 ± 1.17# | 11.37 ± 1.95# |
|
| |||||
| Cu–Zn (SOD)—units/mg | |||||
| C | 13.44 ± 2.83 | 10.89 ± 2.64 | 21.25 ± 4.55 | 19.88 ± 3.58 | 13.60 ± 4.61 |
| LN | 9.21 ± 1.59 | 6.74 ± 1.31* | 12.37 ± 1.88* | 11.52 ± 1.03* | 8.66 ± 2.09* |
| LN + AS | 13.03 ± 0.09# | 7.26 ± 1.43 | 12.07 ± 2.51* | 22.13 ± 3.03# | 9.86 ± 2.54* |
|
| |||||
| Glutathione (GSH)—units/minute/g | |||||
| C | 3.34 ± 0.09 | 4.11 ± 0.13 | 3.48 ± 0.09 | 3.71 ± 0.11 | 3.22 ± 0.39 |
| LN | 3.28 ± 0.07 | 3.69 ± 0.16 | 3.29 ± 0.05 | 3.16 ± 0.12 | 3.45 ± 0.21 |
| LN + AS | 3.56 ± 0.09 | 3.92 ± 0.13 | 3.59 ± 0.05 | 3.54 ± 0.11 | 3.89 ± 0.31 |
|
| |||||
| Lipid peroxidation (LPx)—nmoles MDA/mL | |||||
| C | 10.43 ± 2.31 | 20.07 ± 1.87 | 4.78 ± 0.23 | 5.29 ± 0.22 | 10.76 ± 0.53 |
| LN | 23.66 ± 1.75* | 22.30 ± 0.53* | 13.75 ± 1.71* | 12.05 ± 1.03* | 18.97 ± 1.65* |
| LN + AS | 11.42 ± 0.83# | 14.61 ± 0.67# | 09.82 ± 1.04∗# | 06.39 ± 0.67# | 14.61 ± 0.82∗# |
Data are expressed as mean ± SEM. P < 0.05 was considered significant. *represents significant difference compared to control group. #represents significant difference compared to lead treated animals (LN group).