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Niacin and simvastatin decreased the level of plasma MDA in guinea pigs after treatment for 8 weeks. MDA was determined by a spectrophotometric measurement of thiobarbituric acid-reactive substances (TBARS) according to the manufacturer's instruction. Data are presented as mean ± SD (n = 8). ## P < 0.01 versus CD group; **P < 0.01 versus HFD group.
