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Effect of niacin and simvastatin on the mRNA abundance of SR-B1, LDL-R, CYP7A1, and HMGCR in liver of guinea pigs fed high fat diet. The mRNA levels, which were analyzed by quantitative real-time PCR, were calculated after being adjusted for β-actin using the 2−ΔΔCt method. Data are presented as mean ± SD of at least three independent experiments. # P < 0.05; ## P < 0.01 versus CD group; **P < 0.01 versus HFD group.
