Figure 1.
Effect of PTU-induced hypothyroidism and its reversal by T3 upon oxidative damage to mitochondrial membrane lipids. (a) Endogenous membrane lipid peroxidation (TBARS formed) in submitochondrial particles (SMP) isolated from liver of rats. (b) In vitro oxidant-induced TBARS level for which SMP were incubated without any oxidant and with H2O2 (600 nmol/mg protein) and tert-butyl hydroperoxide (600 nmol/mg protein), respectively, for 1 h at 37°C prior to TBARS determination. Data are means ± S.D. of five animals/group. Statistical significance is denoted by *P < 0.05, **P < 0.01, and ***P < 0.001 compared to euthyroid rats; ‡ P < 0.005 compared to hypothyroid rats.