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Effect of PTU-induced hypothyroidism and its reversal by T3 upon mitochondrial ROS and ROS-metabolizing enzymes. (a) Superoxide radical generation capacity of submitochondrial particles. (b) Superoxide dismutase activity in the mitochondrial matrix fraction isolated from liver of rats. Data are means ± S.D. of five animals/group. Statistical significance is denoted by *P < 0.005 and **P < 0.001 compared to euthyroid rats;‡ P < 0.001 compared to hypothyroid rats.
