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. 2014 Jun 1;2014:697560. doi: 10.1155/2014/697560

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Copyright © 2014 Lu Li et al.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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5-LO specific inhibitor AA-861 prevented hepatocellular necrosis in D-GalN/LPS-treated rats. Representative photomicrographs of liver sections stained with hematoxylin and eosin from the control group receiving placebo (left panels), 24 hr D-GalN/LPS-treated rats receiving placebo (middle panels), and 24 hr D-GalN/LPS-treated rats receiving AA-861 (right panels). Confluent necrosis score and spotty lytic necrosis, apoptosis, and focal inflammation score in Modified Histological Activity Index system were employed. Control: 0; D-GalN/LPS: 9; AA-861 + D-GalN/LPS: 2.