Table 2.

Pharmacokinetic parameters of puerarin after an intravenous administration of puerarin (40 mg/kg) to rats in the presence and absence of piperine and white pepper (n = 6, mean ± SD).

Parameters	Control	With piperine		With white pepper
		10 mg/kg	20 mg/kg	125 mg/kg	250 mg/kg
AUC0–t (μg/mL·h)	83.665 ± 19.132	89.287 ± 23.868	80.638 ± 15.667	95.826 ± 20.052	102.026 ± 24.22*
AUC0–∞ (μg/mL·h)	90.221 ± 17.419	98.366 ± 23.219	91.982 ± 12.127	104.132 ± 21.774	115.27 ± 20.435*
V d (L/kg)	0.365 ± 0.123	0.363 ± 0.07	0.402 ± 0.119	0.366 ± 0.19	0.542 ± 0.301
CL (L/h/kg)	0.433 ± 0.109	0.389 ± 0.118	0.441 ± 0.058	0.413 ± 0.098	0.384 ± 0.097
t 1/2 (h)	0.715 ± 0.201	0.702 ± 0.204	0.652 ± 0.247	0.759 ± 0.186	0.929 ± 0.281

Asterisks signs designate significant differences: *P < 0.05 versus control group given puerarin only.