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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005612. doi: 10.1002/14651858.CD005612.pub2

Comparison 1. Pregabalin versus placebo: 50% seizure reduction - ITT.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 50% responders, ITT 6 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 1.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 95% CI) 1.06 [0.52, 2.12]
 1.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 95% CI) 2.22 [1.36, 3.63]
 1.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 95% CI) 2.86 [1.65, 4.94]
 1.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 95% CI) 2.86 [2.32, 3.54]
 1.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 95% CI) 2.86 [1.42, 5.76]
1.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 95% CI) 2.55 [2.06, 3.16]
2 50% responders (random effects) 6 1868 Risk Ratio (M-H, Random, 95% CI) 2.61 [1.70, 4.01]
3 50% responders, Best Case Analysis 6 4206 Risk Ratio (M-H, Fixed, 95% CI) 3.72 [3.27, 4.23]
 3.1 50mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 95% CI) 1.87 [1.03, 3.40]
 3.2 150mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 95% CI) 2.61 [1.63, 4.19]
 3.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 95% CI) 4.37 [2.61, 7.29]
 3.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 95% CI) 4.09 [3.34, 5.01]
 3.5 Titrated dose of pregabalin (150-600mg) 1 204 Risk Ratio (M-H, Fixed, 95% CI) 5.02 [2.56, 9.82]
 3.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 95% CI) 3.60 [2.93, 4.43]
4 50% responders, Best Case Analysis Random Effects 6 3240 Risk Ratio (M-H, Random, 95% CI) 1.50 [0.92, 2.45]
 4.1 600 mg pregabalin 6 1372 Risk Ratio (M-H, Random, 95% CI) 1.64 [0.78, 3.44]
 4.2 Any dose pregabalin 6 1868 Risk Ratio (M-H, Random, 95% CI) 1.40 [0.65, 3.00]
5 50% responders, Worst Case Analysis 6 4206 Risk Ratio (M-H, Fixed, 95% CI) 1.05 [0.96, 1.14]
 5.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 95% CI) 0.55 [0.30, 0.99]
 5.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 95% CI) 1.32 [0.88, 1.96]
 5.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 95% CI) 1.48 [0.98, 2.23]
 5.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 95% CI) 1.24 [1.08, 1.43]
 5.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 95% CI) 0.35 [0.27, 0.46]
 5.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 95% CI) 1.08 [0.94, 1.23]