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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005612. doi: 10.1002/14651858.CD005612.pub2

Comparison 2. Pregabalin versus placebo: seizure freedom - ITT.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Seizure freedom post titration 6 Risk Ratio (M-H, Fixed, 95% CI) Subtotals only
 1.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 95% CI) 3.40 [0.14, 82.52]
 1.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 95% CI) 0.33 [0.01, 7.92]
 1.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 95% CI) 0.0 [0.0, 0.0]
 1.4 600 mg pregabalin 6 1880 Risk Ratio (M-H, Fixed, 95% CI) 2.45 [1.02, 5.91]
 1.5 Titrated dose of pregabalin (150-600mg) 1 204 Risk Ratio (M-H, Fixed, 95% CI) 5.05 [0.28, 92.42]
 1.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 95% CI) 2.59 [1.05, 6.36]