. Author manuscript; available in PMC: 2014 Jun 16.

Published in final edited form as: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005612. doi: 10.1002/14651858.CD005612.pub2

Comparison 4. Pregabalin versus placebo: treatment withdrawal (adverse events) - ITT.

Outcome or subgroup title	No. of studies	No. of participants	Statistical method	Effect size
1 Treatment withdrawal for adverse events	6		Risk Ratio (M-H, Fixed, 95% CI)	Subtotals only
1.1 50 mg pregabalin	1	188	Risk Ratio (M-H, Fixed, 95% CI)	1.36 [0.43, 4.31]
1.2 150 mg pregabalin	2	384	Risk Ratio (M-H, Fixed, 95% CI)	1.02 [0.45, 2.32]
1.3 300 mg pregabalin	1	190	Risk Ratio (M-H, Fixed, 95% CI)	2.89 [1.07, 7.78]
1.4 600 mg pregabalin	6	1372	Risk Ratio (M-H, Fixed, 95% CI)	3.39 [2.36, 4.87]
1.5 Titrated dose of pregabalin (150-600 mg)	1	204	Risk Ratio (M-H, Fixed, 95% CI)	1.78 [0.68, 4.67]
1.6 Any dose pregabalin	6	1868	Risk Ratio (M-H, Fixed, 95% CI)	2.69 [1.88, 3.86]