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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Cochrane Database Syst Rev. 2008 Jan 23;(1):CD005612. doi: 10.1002/14651858.CD005612.pub2

Comparison 5. Pregabalin versus placebo: adverse effects.

Outcome or subgroup title No. of studies No. of participants Statistical method Effect size
1 Ataxia 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 1.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 1.14 [0.14, 9.00]
 1.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 1.98 [0.56, 7.01]
 1.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 3.33 [0.62, 17.81]
 1.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 99% CI) 4.93 [2.56, 9.48]
 1.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 2.23 [0.44, 11.26]
 1.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 3.90 [2.05, 7.42]
2 Fatigue 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 2.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 0.71 [0.17, 2.94]
 2.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 1.09 [0.50, 2.39]
 2.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 1.53 [0.49, 4.76]
 2.4 600 mg pregabalin 6 1503 Risk Ratio (M-H, Fixed, 99% CI) 1.32 [0.89, 1.95]
 2.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 1.23 [0.49, 3.04]
 2.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 1.28 [0.88, 1.86]
3 Dizziness 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 3.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 1.01 [0.31, 3.33]
 3.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 2.04 [0.99, 4.22]
 3.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 3.46 [1.39, 8.62]
 3.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 99% CI) 3.57 [2.50, 5.09]
 3.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 2.97 [1.01, 8.77]
 3.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 3.06 [2.16, 4.34]
4 Nausea 3 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 4.1 150 mg pregabalin 1 196 Risk Ratio (M-H, Fixed, 99% CI) 1.31 [0.34, 5.00]
 4.2 600 mg pregabalin 3 712 Risk Ratio (M-H, Fixed, 99% CI) 1.18 [0.51, 2.75]
 4.3 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 1.11 [0.12, 10.05]
 4.4 Any dose pregabalin 3 942 Risk Ratio (M-H, Fixed, 99% CI) 1.14 [0.51, 2.53]
5 Somnolence 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 5.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 0.93 [0.31, 2.78]
 5.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 1.26 [0.58, 2.74]
 5.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 1.62 [0.63, 4.12]
 5.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 99% CI) 2.42 [1.68, 3.50]
 5.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 2.32 [0.77, 7.04]
 5.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 2.08 [1.45, 2.99]
6 Weight gain 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 6.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 3.40 [0.05, 224.69]
 6.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 3.85 [0.64, 23.35]
 6.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 14.43 [0.34, 620.87]
 6.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 99% CI) 5.61 [2.74, 11.47]
 6.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 2.79 [0.84, 9.29]
 6.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 4.92 [2.41, 10.03]
7 Headache 6 Risk Ratio (M-H, Fixed, 99% CI) Subtotals only
 7.1 50 mg pregabalin 1 188 Risk Ratio (M-H, Fixed, 99% CI) 0.52 [0.16, 1.77]
 7.2 150 mg pregabalin 2 384 Risk Ratio (M-H, Fixed, 99% CI) 0.53 [0.24, 1.17]
 7.3 300 mg pregabalin 1 190 Risk Ratio (M-H, Fixed, 99% CI) 0.43 [0.12, 1.57]
 7.4 600 mg pregabalin 6 1372 Risk Ratio (M-H, Fixed, 99% CI) 0.77 [0.51, 1.15]
 7.5 Titrated dose of pregabalin (150-600 mg) 1 204 Risk Ratio (M-H, Fixed, 99% CI) 1.25 [0.45, 3.50]
 7.6 Any dose pregabalin 6 1868 Risk Ratio (M-H, Fixed, 99% CI) 0.75 [0.52, 1.08]