Table 2. Gene analysis results for the vascular tone pathway using data from the combined GLAUGEN and NEIGHBOR.

Protein	Label in Figure 2.	Gene (Ensembl ID)	Chr	No. of simplea features	No. of complexa features	POAG	POAG with early paracentral visual field loss	POAG with peripheral visual field loss only
						P-valueb	P-valueb	P-valueb
5′ AMP-activated protein kinase	AMPK	PRKAA1c	5	0	2	<0.001	0.05	0.05
Inositol 1,4,5-trisphosphate receptor, type 3	IP3R	ITPR3c	6	14	9	<0.001	<0.001	>0.99
Hemochromatosis protein	—	HFE	6	0	2	<0.001	<0.001	0.07
Caveolin-1/caveolin 2	CAV1	CAV1c	7	2	6	<0.001	<0.001	0.004
G-protein subunit β-2	G beta	GNB2c	7	0	2	<0.001	>0.99	>0.99
Endothelin receptor type B	ETB	EDNRBc	13	0	1	<0.001	<0.001	>0.99
Dynamin II	Dyn2	DNM2c	19	2	7	<0.001	0.06	>0.99
Myosin regulatory light polypeptide 9	MLC	MYL9	20	0	1	<0.001	>0.99	>0.99

Abbreviations: Chr, chromosome; GLAUGEN, the Glaucoma Genes and Environment study; LD, linkage disequilibrium; NEIGHBOR, National Eye Institute Glaucoma Human Genetics Collaboration; POAG, primary open-angle glaucoma; SNP, single-nucleotide polymorphism.

^aSimple features refer to single SNPs not in any LD block; complex features refer to LD blocks with two or more SNPs.

^bP-values are permuted P-values.

^cGenes for proteins that interact with endothelial nitric oxide synthase; see Figure 2.