Table 2. Mean values of SDOCT retinal nerve fiber layer thickness parameters in glaucoma and control eyes with areas under the receiver operating characteristic curves and sensitivities at fixed specificities.
| Retinal nerve fiber layer parameters (in microns) | Control (mean±SD) | Glaucoma (mean±SD) | P-value | AUC | Sensitivity at 95% specificity | Sensitivity at 80% specificity |
|---|---|---|---|---|---|---|
| Signal strength index | 51±10 | 47±9 | 0.003 | |||
| Temporal quadrant | 79.1±10.6 | 65.9±14.7 | <0.001 | 0.802 (0.735–0.861) | 44.3% (26.3–58.3) | 67.0% (55.0–76.8) |
| Superior quadrant | 122.8±18.1 | 95.2±19.2 | <0.001 | 0.823 (0.746–0.888) | 49.1% (25.0–61.9) | 79.2% (70.5–90.2) |
| Nasal quadrant | 78.5±12.6 | 67.2±16.4 | <0.001 | 0.678 (0.583–0.768) | 28.3% (16.5–43.0) | 48.1% (34.2–63.5) |
| Inferior quadrant | 126.6±19.4 | 93.6±16.6 | <0.001 | 0.876 (0.819–0.927) | 53.8% (33.9–69.6) | 81.1% (66.7–91.5) |
| Average thickness | 101.8±11.3 | 80.5±12.8 | <0.001 | 0.868 (0.801–0.915) | 63.2% (42.6–77.2) | 78.3% (64.0–86.5) |
Abbreviations: AUC, area under the receiver operating characteristic curve; SD, standard deviation; SDOCT, spectral domain optical coherence tomograph.
Figures in brackets are 95% confidence intervals. AUCs and sensitivities are adjusted for the difference in disc area and signal strength index between the control and glaucoma group.