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. Author manuscript; available in PMC: 2015 Apr 1.
Published in final edited form as: Nat Rev Endocrinol. 2014 Feb 18;10(4):198–205. doi: 10.1038/nrendo.2014.11

Figure 1.

Figure 1

Cumulative number of T2DM loci discovered and T2DM risk per risk allele, by year, since 2000. The left axis (red squares) indicates the number of replicated, genome-wide significant loci associated with T2DM identified during the period 2000–2012 in populations of European, South Asian and East Asian ancestry. No such loci were discovered before 2000. The right axis (blue circles) indicates the cumulative mean effect size, expressed as the odds ratio, for the index variants at loci discovered from 2006 to 2012.1 As the number of T2DM loci identified has increased over time, the mean odds ratio has fallen from 1.197 for the three variants known in 2006 to 1.089 for the 65 variants known in 2012. These values equate to a fall from 19.7% increased mean odds ratio per additional risk allele in 2006 to 8.9% in 2012. Abbreviation: T2DM, type 2 diabetes mellitus.