Table 3.
Genes | Risk factors | Methylated | Control (n = 16) | PMOLs (n = 54) | OSCC (n = 76) | P valuea |
---|---|---|---|---|---|---|
MGMT | Tobacco chewers (N) | N | 9 | 51 | 59 | |
Tissue | 2 (22%) | 24 (47%) | 52 (88%) | 0.041 | ||
Blood | 1 (11%) | 14 (27%) | 39 (66%) | 0.015 | ||
Alcohol consumers (N) | N | 5 | 12 | 19 | ||
Tissue | 0 (0%) | 8 (67%) | 10 (53%) | 0.1588 | ||
Blood | 0 (0%) | 7 (58%) | 7 (37%) | 0.259 | ||
Pan masala (N) | N | 3 | 25 | 23 | ||
Tissue | 1 (33%) | 15 (60%) | 14 (61%) | 0.877 | ||
Blood | 0 (0%) | 8 (32%) | 14 (61%) | 0.236 | ||
Bidi smokers (N) | N | 10 | 35 | 43 | ||
Tissue | 2 (20%) | 20 (57%) | 38 (88%) | 0.038 | ||
Blood | 1 (10%) | 15 (43%) | 33 (77%) | 0.048 | ||
| ||||||
p16 | Tobacco chewers (N) | N | 9 | 51 | 59 | |
Tissue | 2 (22%) | 25 (49%) | 51 (86%) | 0.049 | ||
Blood | 0 (0%) | 18 (35%) | 50 (85%) | 0.088 | ||
Alcohol consumers (N) | N | 5 | 12 | 19 | ||
Tissue | 0 (0%) | 8 (67%) | 11 (58%) | 0.124 | ||
Blood | 0 (0%) | 6 (50%) | 8 (42%) | 0.278 | ||
Pan masala (N) | N | 3 | 25 | 23 | ||
Tissue | 2 (67%) | 19 (76%) | 18 (78%) | 0.015 | ||
Blood | 0 (0%) | 11 (44%) | 17 (74%) | 0.107 | ||
Bidi smokers (N) | N | 10 | 35 | 43 | ||
Tissue | 2 (20%) | 29 (83%) | 40 (93%) | 0.007 | ||
Blood | 0 (0%) | 15 (43%) | 38 (88%) | 0.071 |
aChi-square test; n = total number of samples in the group; N = number of individuals exposed to risk factors in different groups. Significant P value represented with bold.