Table 3.
Correlation of promoter methylation with risk factors in different groups.
| Genes | Risk factors | Methylated | Control (n = 16) | PMOLs (n = 54) | OSCC (n = 76) | P valuea |
|---|---|---|---|---|---|---|
| MGMT | Tobacco chewers (N) | N | 9 | 51 | 59 | |
| Tissue | 2 (22%) | 24 (47%) | 52 (88%) | 0.041 | ||
| Blood | 1 (11%) | 14 (27%) | 39 (66%) | 0.015 | ||
| Alcohol consumers (N) | N | 5 | 12 | 19 | ||
| Tissue | 0 (0%) | 8 (67%) | 10 (53%) | 0.1588 | ||
| Blood | 0 (0%) | 7 (58%) | 7 (37%) | 0.259 | ||
| Pan masala (N) | N | 3 | 25 | 23 | ||
| Tissue | 1 (33%) | 15 (60%) | 14 (61%) | 0.877 | ||
| Blood | 0 (0%) | 8 (32%) | 14 (61%) | 0.236 | ||
| Bidi smokers (N) | N | 10 | 35 | 43 | ||
| Tissue | 2 (20%) | 20 (57%) | 38 (88%) | 0.038 | ||
| Blood | 1 (10%) | 15 (43%) | 33 (77%) | 0.048 | ||
|
| ||||||
| p16 | Tobacco chewers (N) | N | 9 | 51 | 59 | |
| Tissue | 2 (22%) | 25 (49%) | 51 (86%) | 0.049 | ||
| Blood | 0 (0%) | 18 (35%) | 50 (85%) | 0.088 | ||
| Alcohol consumers (N) | N | 5 | 12 | 19 | ||
| Tissue | 0 (0%) | 8 (67%) | 11 (58%) | 0.124 | ||
| Blood | 0 (0%) | 6 (50%) | 8 (42%) | 0.278 | ||
| Pan masala (N) | N | 3 | 25 | 23 | ||
| Tissue | 2 (67%) | 19 (76%) | 18 (78%) | 0.015 | ||
| Blood | 0 (0%) | 11 (44%) | 17 (74%) | 0.107 | ||
| Bidi smokers (N) | N | 10 | 35 | 43 | ||
| Tissue | 2 (20%) | 29 (83%) | 40 (93%) | 0.007 | ||
| Blood | 0 (0%) | 15 (43%) | 38 (88%) | 0.071 | ||
aChi-square test; n = total number of samples in the group; N = number of individuals exposed to risk factors in different groups. Significant P value represented with bold.