Table 1.

Included studies.

Author	Year	Study design	Thermal water/control	Application	Adverse events	MCT	Flow	Resistance	IgA	IgE	IgG	IgM
De Luca et al. [53]	2006	Prospective, nonrandomized, noncontrolled	Sulphur/—	Inhalation 1x daily 10 min for 12 days	X	X
Marullo and Abramo [29]	2000	Prospective, nonrandomized, controlled, double-blind	Radon/Tap water	Inhalation 10 min, Aerosol 10 min, 1x daily for 12 days	X	X	X	X
Miraglia del Giudice et al. [60]	2011	Prospective, randomized, controlled	Hypermineral chloride sodium water/ISCS	Aerosol 15 days a month for 3 months/ ISCS daily for 3 months	X
Ottaviano et al. [27]	2012	Prospective, randomized, controlled, double-blind	Sulphur-Arsenic-Ferrous water diluted to 10% solution with distilled water/ISCS	Irrigation 1x daily 20 mL for 1 month	X			X
Ottaviano et al. [28]	2011	Prospective, randomized, controlled, double-blind	Sulphur-Salt-Bromine-Iodine/ISCS	Irrigation 4x daily 5 mL for 1 month	X			X
Passali et al. [58]	2013	Prospective, nonrandomized, noncontrolled	Radon/—	Inhalation, Aerosol, each 10 min 1x daily for 14 days	X	X	X	X
Passali et al. [59]	2008	Prospective, randomized, controlled	Salt-Bromine-Iodine/ISCS	Inhalation 10 min, Aerosol 10 min, Irrigation 5 min 1x daily for 14 days	X	X
Passariello et al. [57]	2012	Prospective, nonrandomized, noncontrolled	Sulphate-Sodium-Chloride/—	Aerosol 15 min 1x daily for 15 days	X
Salami et al. [26]	2010	Prospective, randomized, controlled, double-blind	Sulphur/ISCS	Inhalation, 10 min Irrigation 6 min 1x daily for 12 days	X	X		X	X	X	X	X
Salami et al. [25]	2008	Prospective, randomized, controlled, double-blind	Sulphur/ISCS	Inhalation 10 min 1x daily for 12 days	X	X			X	X	X	X
Staffieri et al. [56]	2008	Prospective, randomized, controlled	Sulphur-Arsenic-Ferrous water diluted to 10% solution with distilled water/ISCS	Irrigation 4x daily 20 mL for 6 months	X
Staffieri and Abramo [55]	2007	Prospective, nonrandomized, noncontrolled, double-blind	Sulphur-Arsenic-Ferrous water/—	Inhalation, Aerosol each 10 min, 1x daily for 12 days	X	X	X	X
Staffieri et al. [54]	1998	Prospective, randomized, controlled, double-blind	Sulphur-Salt-Bromine-Iodine/distilled water	Inhalation, 10 min, Aerosol 10 min 1x daily for 12 days	X