Table 3.

Type of application.

Application	Inhalation	Inhalation + aerosol	Irrigation	Inhalation + irrigation	Inhalation + aerosol + irrigation	Aerosol
Number of patients	140	117	230	80	120	100
Study	De Luca et al. [53] Salami et al. [25]	Marullo and Abramo [29] Passali et al. [58] Staffieri and Abramo [55] Staffieri et al. [54]	Ottaviano et al. [27] Ottaviano et al. [28] Staffieri et al. [56]	Salami et al. [26]	Passali et al. [59]	Miraglia del Giudice et al. [60] Passariello et al. [57]