Figure 1.

The major transcriptional pathways that control ILC and NK cell development. Indicated in red are the key transcription factors that have been shown being absolutely required in vivo for the development of each cell subset. “Emergency” NK cells are NK cells that develop in the absence of E4BP4, following viral infection. It is presently unclear whether these cells are Tbet-dependent. CHILP, common helper innate lymphoid precursor; CLP, common lymphoid progenitor; cILC2/ILC3p, common ILC2/ILC3 progenitor.