Table 1.
CD127 | IL-15 dependence | IL-7 dependence | TBX21 dependence | Eomes dependence | E4BP4 dependence | Human counterpart | |
---|---|---|---|---|---|---|---|
siLP ILC1 | +++ | Yes | No | Yes | No | Partial | Most likely CD127+CD56−CD94−mucosal cells |
Intraepithelial ILC1 | − | Partial | No | Yes | TBD | Yes | CD56+NKp44+ |
CD103+CD160+ cells in human tonsil and intestine | |||||||
“Converted” or “plastic” ILC3 | +++ | No, but IL-15 can promote conversion | Yes | Yes | No | TBD | Mostly generated in vitro |
cNKs (splenic, bone marrow, lymph nodes) | − | Yes | No | Yes | Yes | Yes | Most likely CD56imdimCD16+ blood NKs |
Thymic NK cells | +++ | Yes | Yes | Yes | Yes | Yes | Most likely CD56rightbrightCD16−blood NKs |
Liver-resident CD49a+DX5−NKs/ILC1 | − | Yes | TBD | Yes | No | No | TBD |
Skin-resident CD49a+DX5−NKs | − | Yes | TBD | Yes | TBD | No | TBD |
Uterus-resident CD49a+DX5−NKs | − | Yes | TBD | No | TBD | No | TBD |
Salivary gland NKs | − | Yes | TBD | TBD | TBD | No | TBD |
TBD, to be determined.