Table 3.
HRs for all-cause and cardiovascular mortality according to different levels of apoA-I, apoB, and apoB/apoA-I.
| Variable | Number of deaths | Person-years | Hazard ratios (95% confidence intervals) | ||||||
|---|---|---|---|---|---|---|---|---|---|
| All-cause mortality | CVD mortality | ||||||||
| Total | CVD | Model 1a | Model 2b | Model 3c | Model 1a | Model 2b | Model 3c | ||
| ApoA-I | |||||||||
| Quartile 1 | 51 | 41 | 1255 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Quartile 2 | 34 | 25 | 1486 | 0.57 (0.37–0.88) | 0.60 (0.38–0.94) | 0.59 (0.38–0.92) | 0.53 (0.32–0.88) | 0.55 (0.33–0.93) | 0.55 (0.33–0.91) |
| Quartile 3 | 26 | 19 | 1603 | 0.43 (0.26–0.69) | 0.43 (0.26–0.71) | 0.43 (0.26–0.70) | 0.39 (0.23–0.69) | 0.40 (0.23–0.70) | 0.39 (0.22–0.70) |
| Quartile 4 | 36 | 28 | 1653 | 0.52 (0.34–0.81) | 0.54 (0.34–0.86) | 0.56 (0.35–0.88) | 0.52 (0.31–0.85) | 0.55 (0.33–0.93) | 0.57 (0.34–0.95) |
| P for trend | 0.002 | 0.004 | 0.004 | 0.003 | 0.008 | 0.007 | |||
| ApoB (mg/dL) | |||||||||
| <90 | 102 | 77 | 4301 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| 90–109 | 30 | 23 | 1104 | 1.33 (0.88–2.00) | 1.35 (0.88–2.06) | 1.35 (0.89–2.07) | 1.36 (0.85–2.17) | 1.38 (0.85–2.24) | 1.39 (0.86–2.26) |
| ≥110 | 15 | 13 | 593 | 1.74 (1.00–3.04) | 1.80 (1.02–3.19) | 1.72 (0.97–3.04) | 2.00 (1.09–3.66) | 2.13 (1.14–3.97) | 2.06 (1.10–3.85) |
| P for trend | 0.09 | 0.07 | 0.10 | 0.06 | 0.04 | 0.05 | |||
| ApoB/apoA-I | |||||||||
| Quartile 1 | 29 | 21 | 1591 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 | 1.00 |
| Quartile 2 | 37 | 28 | 1547 | 1.43 (0.88–2.34) | 1.39 (0.85–2.29) | 1.34 (0.81–2.21) | 1.50 (0.85–2.66) | 1.43 (0.80–2.55) | 1.38 (0.77–2.48) |
| Quartile 3 | 40 | 29 | 1496 | 1.43 (0.88–2.32) | 1.44 (0.87–2.37) | 1.42 (0.86–2.34) | 1.42 (0.80–2.51) | 1.36 (0.76–2.44) | 1.34 (0.74–2.41) |
| Quartile 4 | 41 | 35 | 1362 | 2.18 (1.34–3.58) | 2.06 (1.24–3.41) | 2.00 (1.21–3.31) | 2.58 (1.47–4.51) | 2.38 (1.34–4.23) | 2.33 (1.32–4.14) |
| P for trend | 0.019 | 0.046 | 0.058 | 0.007 | 0.037 | 0.023 | |||
aModel 1 was adjusted for age, gender, education, marriage, leisure-time physical activity, smoking, and alcohol drinking.
bModel 2 was adjusted for model 1 covariates plus type, severity, duration, and treatment of CAD, history of diabetes, history of heart failure, BMI, systolic blood pressure, glomerular filtration rate, and use of antihypertensive drugs, antidiabetic drugs, and antiplatelet drugs.
cModel 3 was adjusted for model 2 covariates plus use of cholesterol-lowering drugs.