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Interactive impact of the SNPs, gender and age on clinical covariates (T, N, M, stage). The interactive effects of BRCA1 rs16941 and gender on N-status (A) and stage (B), BRCA1 rs16941 and age on T-status (C), and between ATM and gender on T-status were examined by fitting the full regression model for each pair (logistic for M status, linear for other clinical variables). No male cases with the rare AA genotype of ATM were observed.
