. Author manuscript; available in PMC: 2014 Jun 16.

Published in final edited form as: Int J Cancer. 2013 Jun 12;133(10):2444–2453. doi: 10.1002/ijc.28266

Table 4.

Risk of adult cancer in relatives of 4,482 pediatric cases diagnosed in Utah from 1966 to 2009

	Index cases	Matched controls	First-degree relatives, LFS cancer at ages 19–55						First-degree relatives, non-LFS cancer at ages 19–55
			Relatives of cases		Relatives of controls				Relatives of cases		Relatives of controls
			Diagnosed	Undiagnosed	Diagnosed	Undiagnosed			Diagnosed	Undiagnosed	Diagnosed	Undiagnosed

Cancer of pediatric case	N		N				OR (95% CI)	p	N				OR (95% CI)	p
Any cancer, ages 0–4	1,552	7,760	26	2,858	63	16,053	2.2 (1.4–3.5)	<10^–3	52	2,832	212	15,904	1.3 (1.0–1.8)	0.10
Any cancer, ages 0–18	4,482	22,410	75	8,778	244	50,702	1.7 (1.3–2.1)	<10^–3	166	8,687	711	50,235	1.3 (1.1–1.5)	<0.01
ICCC-3 classification, ages 0–18
Leukemias, myeloproliferative	1,150	5,750	22	2,040	56	12,607	2.2 (1.3–3.5)	<10^–3	35	2,027	155	12,508	1.2 (0.9–1.8)	0.28
CNS and intracranial/spinal	870	4,350	13	1,805	37	9,796	1.8 (1.0–3.5)	0.06	29	1,789	139	9,694	1.1 (0.7–1.6)	0.72
Lymphomas, reticuloendothelial	578	2,890	9	1,076	34	6,688	1.5 (0.7–3.1)	0.29	25	1,060	105	6,617	1.4 (0.9–2.1)	0.17
Other epithelial, melanomas	480	2,400	11	1,002	34	5,522	1.7 (0.9–3.5)	0.12	20	993	66	5,490	1.6 (1.0–2.7)	0.06
Soft tissue, other sarcomas	304	1,520	6	625	20	3,561	1.6 (0.6–3.9)	0.35	8	623	54	3,527	0.8 (0.4–1.6)	0.84
Malignant bone tumors	258	1,290	8	534	24	3,107	1.6 (0.7–3.6)	0.25	16	526	60	3,071	1.3 (0.7–2.3)	0.38
Neuroblastoma, nervous cell	254	1,270	4	432	19	2,700	1.4 (0.5–4.1)	0.59	12	424	25	2,694	3.1 (1.5–6.4)	<0.01
Germ cell tumors	262	1,310	1	493	16	2,890	0.4 (0.1–2.7)	0.31	8	486	47	2,859	1.0 (0.5–2.1)	0.94
Renal tumors	203	1,015	1	487	17	2,410	0.2 (0.0–1.8)	0.17	10	478	36	2,391	1.2 (0.6–2.4)	0.64
Retinoblastomas	87	435	1	173	7	998	0.7 (0.1–5.7)	0.71	2	172	10	995	1.0 (0.2–4.5)	0.97
Hepatic tumors	60	300	0	100	1	560	Undetermined	–	3	97	8	553	1.8 (0.5–7.1)	0.39

Cases compared to controls matched 5:1 on sex, birth year and birthplace (in Utah or outside of Utah).

Abbreviations: OR: odds ratio from conditional logistic regression; ICCC-3: International Classification of Childhood Cancer, Third edition¹³; CNS: central nervous system.