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. Author manuscript; available in PMC: 2014 Jun 16.
Published in final edited form as: Curr Biol. 2012 May 22;22(10):R414–R424. doi: 10.1016/j.cub.2012.03.004

Figure 1. Lipid metabolism and formation of transport carriers.

Figure 1

This diagram highlights existing views of the interface between lipid metabolism and components of the protein machinery which drives formation of vesicles or tubular transport carriers in mammals. No obvious CERT- or PKD activities are present in yeast, and yeast do not exhibit obvious counterparts for BARS, endophilin or LPAATs. The dissonance between this diagram and in vivo readouts for PLD, BARS and CERT function in mammals is discussed in the text. Abbreviations: Cer, ceramide; LPC, lyso-PtdCho; PAP, PtdOH phosphatase; SM, sphingomyelin; SMS, sphingomyelin synthase.