Table 3.
Incidence Rates of Malignancy in PsA and RA per 100 Patient Years
| PsA | RA | PsA vs. RA | ||||||
|---|---|---|---|---|---|---|---|---|
| Count | Total PY for Event |
IR (95% CI) | Count | Total PY for Event |
IR (95% CI) | IRR | P value | |
| All cancers* | 40 | 7156.1 | 0.56 (0.40, 0.76) | 307 | 54709.7 | 0.56 (0.50, 0.63) | 1.00 (0.70, 1.36) | 0.864 |
| NMSC | 15 | 7099.0 | 0.21 (0.12, 0.35) | 109 | 54136.8 | 0.20 (0.17, 0.24) | 1.05 (0.61, 1.80) | 0.854 |
| non-NMSC** | 25 | 7121.9 | 0.35 (0.23, 0.52) | 198 | 54387.2 | 0.36 (0.32, 0.42) | 0.97 (0.61, 1.42) | 0.725 |
| Solid | 20 | 7112.8 | 0.28 (0.17, 0.43) | 168 | 54294.0 | 0.31 (0.26, 0.36) | 0.90 (0.57, 1.45) | 0.691 |
| Breast | 7 | 3580.0 | 0.20 (0.08, 0.40) | 55 | 41025.4 | 0.13 (0.10, 0.17) | 1.54 (0.67, 3.23) | 0.338 |
| Prostate | 3 | 3477.4 | 0.09 (0.02, 0.25) | 20 | 12747.5 | 0.16 (0.10, 0.24) | 0.56 (0.16, 1.86) | 0.338 |
| Colorectal | 3 | 7073.9 | 0.04 (0.01, 0.12) | 14 | 53847.2 | 0.03 (0.01, 0.04) | 1.33 (0.47, 5.70) | 0.438 |
| Melanoma | 3 | 7068.8 | 0.04 (0.01, 0.12) | 15 | 53850.4 | 0.03 (0.02, 0.05) | 1.33 (0.44, 5.28) | 0.502 |
| Hematologic | 5 | 7074.1 | 0.07 (0.02, 0.16) | 30 | 53907.6 | 0.06 (0.04, 0.08) | 1.17 (0.36, 2.89) | 0.971 |
| Lymphoma | 3 | 7069.7 | 0.04 (0.01, 0.12) | 21 | 53874.8 | 0.04 (0.02, 0.06) | 1.00 (0.17, 3.11) | 0.668 |
| Multiple myeloma | 1 | 7067.1 | 0.01 (0.00, 0.08) | 1 | 53821.2 | 0.00 (0.00, 0.01) | 7.78 (0.48, 122.23) | 0.150 |
| Leukemia | 1 | 7067.1 | 0.01 (0.00, 0.08) | 8 | 53840.2 | 0.01 (0.01, 0.03) | 1.00 (0.12, 7.64) | 0.966 |
*
All cancers=NMSC + non-NMSC.
**
Non-NMSC=Solid + Hematologic